(-)-JQ-1
Names
[ CAS No. ]:
1268524-71-5
[ Name ]:
(-)-JQ-1
[Synonym ]:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
2-Methyl-2-propanyl [(6R)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate
(R)-(-)-JQ1 Enantiomer
Biological Activity
[Description]:
[Related Catalog]:
[Target]
BET bromodomain[1]
[In Vitro]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
610.4±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C23H25ClN4O2S
[ Molecular Weight ]:
456.988
[ Flash Point ]:
322.9±34.3 °C
[ Exact Mass ]:
456.138672
[ PSA ]:
97.61000
[ LogP ]:
4.49
[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C
[ Index of Refraction ]:
1.657
[ Storage condition ]:
-20°C
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Articles
Nat. Rev. Drug Discov. 13(5) , 337-56, (2014)
Lysine acetylation is a key mechanism that regulates chromatin structure; aberrant acetylation levels have been linked to the development of several diseases. Acetyl-lysine modifications create dockin...
Epigenetic chemical probes. Müller S and Brown PJClin. Pharmacol. Ther. 92(6) , 689-93, (2012)
Targeting chromatin readers. James LI and Frye SV
Clin. Pharmacol. Ther. 93(4) , 312-4, (2013)