Sulfabenzamide

Names

[ CAS No. ]:
127-71-9

[ Name ]:
Sulfabenzamide

[Synonym ]:
Benzamide, N-[(4-aminophenyl)sulfonyl]-
N-[(4-Aminophenyl)sulfonyl]benzamide
N-(4-Aminobenzenesulfonyl)benzamide
4-Amino-N-benzoylbenzenesulfonamide
N-Benzoylsulfanilamide
Sulfabenzamide
N-(4-aminophenyl)sulfonylbenzamide
MFCD00044890
Sulfabenzamide(SB)
Sultrin
EINECS 204-859-4

Biological Activity

[Description]:

Sulfabenzamide is a intermediate in the synthesis of organic and pharmaceutical.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
180-184 °C

[ Molecular Formula ]:
C₁₃H₁₂N₂O₃S

[ Molecular Weight ]:
276.311

[ Exact Mass ]:
276.056854

[ PSA ]:
97.64000

[ LogP ]:
1.19

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
0.3 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV5802500

CHEMICAL NAME :: Benzamide, N-sulfanilyl-

CAS REGISTRY NUMBER :: 127-71-9

BEILSTEIN REFERENCE NO. :: 2139003

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-N2-O3-S

MOLECULAR WEIGHT :: 276.33

WISWESSER LINE NOTATION :: ZR DSWMVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03348

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
N

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ RTECS ]:
CV5802500

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Developing structure-activity relationships for the prediction of hepatotoxicity.

Chem. Res. Toxicol. 23 , 1215-22, (2010)

Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals ...

A predictive ligand-based Bayesian model for human drug-induced liver injury.

Drug Metab. Dispos. 38 , 2302-8, (2010)

Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predicti...