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SNS-062

Names

[ CAS No. ]:
1270014-40-8

[ Name ]:
SNS-062

[Synonym ]:
Acetamide, 2-[(3-chlorophenyl)amino]-N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinyl]-
N-(3-Chlorophenyl)-N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinyl]glycinamide

Biological Activity

[Description]:

BTK IN-1 is a potent BTK inhibitor, with an IC50 of <100 nM.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Research Areas >> Inflammation/Immunology
Research Areas >> Cancer

[Target]

BTK[1]


[In Vitro]

BTK IN-1 (Compound 21) is a potent BTK inhibitor, with an IC50 of <100 nM.

[References]

[1]. Minna Bui, et al. Heteroaryl btk inhibitors. WO2011029043A1


[Related Small Molecules]

Acalabrutinib | GDC-0853 | Evobrutinib | AVL-292 | (±)-Zanubrutinib | ONO-4059 | BMX-IN-1 | GDC-0834 | RN486 | LFM-A13 | Vecabrutinib | CGI-1746 | BMS-986195 | CNX-774 | PRN 1008

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C19H21ClN6O

[ Molecular Weight ]:
384.863

[ Exact Mass ]:
384.146545

[ LogP ]:
2.93

[ Index of Refraction ]:
1.690

Related Compounds