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Selatinib

Names

[ CAS No. ]:
1275595-86-2

[ Name ]:
Selatinib

[Synonym ]:
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfinyl)ethyl]amino]methyl]-2-furanyl]-
6TLR8U8O3C
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfinyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
SELATINIB
UNII:6TLR8U8O3C

Biological Activity

[Description]:

Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:13 nM (IC50)

ErbB2:22.5 nM (IC50)


[References]

[1]. Meng-Na Wang, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020 Dec;38(6):1826-1835.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
740.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H26ClFN4O3S

[ Molecular Weight ]:
565.06

[ Flash Point ]:
401.6±32.9 °C

[ Exact Mass ]:
564.139832

[ LogP ]:
4.81

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.676

Related Compounds