Ganglioside GM2

Names

[ CAS No. ]:
127663-77-8

[ Name ]:
Ganglioside GM2

Biological Activity

[Description]:

Ganglioside GM2 is a human tumor antigen (OFA-I-1). Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Tai T, et al. Ganglioside GM2 as a human tumor antigen (OFA-I-1). Proc Natl Acad Sci U S A. 1983 Sep;80(17):5392-6.

[2]. Anheuser S, et al. Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. J Lipid Res. 2015 Sep;56(9):1747-61.

[3]. Nakamura K, et al. Dissection and optimization of immune effector functions of humanized anti-ganglioside GM2 monoclonal antibody. Mol Immunol. 2000 Dec;37(17):1035-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₇H₁₂₁N₃O₂₆

[ Molecular Weight ]:
1384.68

Related Compounds