5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate

Names

[ Name ]:
5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate

[Synonym ]:
5-(6)-CDCFDA [5(6)-Carboxy-2',7'-dichlorofluorescein Diacetate]
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-
3',6'-Diacetoxy-2',7'-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid

Biological Activity

[Description]:

5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess ROS generation within human neuronal-glial (HNG) cells in primary co-culture[1]

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Pogue AI, et al. Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer. Int J Mol Sci. 2012;13(8):9615-26.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
743.3±60.0 °C at 760 mmHg

[ Melting Point ]:
210ºC (dec.)(lit.)

[ Molecular Formula ]:
C₂₅H₁₄Cl₂O₉

[ Molecular Weight ]:
529.279

[ Flash Point ]:
403.3±32.9 °C

[ Exact Mass ]:
528.001465

[ PSA ]:
125.43000

[ LogP ]:
3.66

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.712

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

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