N-ethylmaleimide

Names

[ CAS No. ]:
128-53-0

[ Name ]:
N-ethylmaleimide

[Synonym ]:
N-ethylmaleimide
EINECS 204-892-4
1H-Pyrrole-2,5-dione, 1-ethyl-
n-ethyl-maleimid
MFCD00005509
1-ethylmaleimide
N-ethyl-maleimide
N-ethylmaleic imide
ethvlmaleimide
n-ethvlmaleimide
1-Ethyl-1H-pyrrole-2,5-dione
N-Ethylmaleinimid
Ethylmaleimide

Biological Activity

[Description]:

N-Ethylmaleimide (NEM) is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

Cysteine protease[1]

[References]

[1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9.

[2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
210.0±9.0 °C at 760 mmHg

[ Melting Point ]:
43-46 °C(lit.)

[ Molecular Formula ]:
C₆H₇NO₂

[ Molecular Weight ]:
125.13

[ Flash Point ]:
73.3±0.0 °C

[ Exact Mass ]:
125.047676

[ PSA ]:
37.38000

[ LogP ]:
0.68

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Storage condition ]:
2-8°C

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.

[ Water Solubility ]:
1 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9625000

CHEMICAL NAME :: 1H-Pyrrole-2,5-dione, 1-ethyl-

CAS REGISTRY NUMBER :: 128-53-0

BEILSTEIN REFERENCE NO. :: 0112448

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H7-N-O2

MOLECULAR WEIGHT :: 125.14

WISWESSER LINE NOTATION :: T5VNVJ B2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1669 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 750 nmol/L

REFERENCE :: 32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives, Proceedings of the International Congress of Radiation Research, 5th, Seattle, 1974," Nygaard, O.F., et al., eds., New York, Academic Press, Inc., 1975 Volume(issue)/page/year: -,742,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4314 No. of Facilities: 132 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2547 (estimated) No. of Female Employees: 1922 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H311-H314-H317

[ Precautionary Statements ]:
P264-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R20/21;R28;R34;R43

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2928 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UX9625000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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