<Suppliers Price>

VP3.15

Names

[ CAS No. ]:
1281681-54-6

[ Name ]:
VP3.15

Biological Activity

[Description]:

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS)[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

IC50: 1.59 μM (PDE7), 0.88 μM (GSK-3)[1]


[References]

[1]. Medina-Rodríguez EM, et al. Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis. Sci Rep. 2017 Mar 3;7:43545.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H22N4OS

[ Molecular Weight ]:
366.48

Related Compounds