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Axillaridine A

Names

[ CAS No. ]:
128255-16-3

[ Name ]:
Axillaridine A

[Synonym ]:
Benzamide, N-[(5α,20S)-20-(dimethylamino)-4-oxopregn-2-en-3-yl]-
axillaridine A
N-[(5α,20S)-20-(Dimethylamino)-4-oxopregn-2-en-3-yl]benzamide
axial-N,N-Dimethyl-4-tert.-butyl-cyclohexylamin

Biological Activity

[Description]:

Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

AChE[1].


[References]

[1]. ul-Haq Z, et al. Molecular dynamics simulation of Axillaridine-A: a potent natural cholinesterase inhibitor. J Enzyme Inhib Med Chem. 2009 Oct;24(5):1101-5.  

[2]. Zhang PZ, et al. Pregnane alkaloids from Sarcococca hookeriana var. digyna. Fitoterapia. 2013 Sep;89:143-8.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
611.4±47.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H42N2O2

[ Molecular Weight ]:
462.667

[ Flash Point ]:
323.6±29.3 °C

[ Exact Mass ]:
462.324615

[ PSA ]:
49.41000

[ LogP ]:
5.40

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.581

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds