Arbutamine

Names

[ Name ]:
Arbutamine

[Synonym ]:
4-[(1R)-1-Hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]-1,2-b enzenediol

Biological Activity

[Description]:

Arbutamine is a short-acting synthetic potent nonselective β-adrenoceptor agonist that increases heart rate, cardiac contractility, and systolic blood pressure[1]. Arbutamine is a catecholamine for a pharmacological cardiac stress agen[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β-adrenoceptor[1]

[In Vivo]

Arbutamine (i.v.; 5, 10, 50, 100, and 250 ng/kg/min) increases mean heart rate, peak positive left ventricular pressure and its first time-derivative, and normal-zone myocardial thickening in 8 open-chest dogs (mean weight, 26.91 kg).

[References]

[1]. Ruiz M, et al. Arbutamine stress perfusion imaging in dogs with critical coronary artery stenoses: (99m)Tc-sestamibi versus (201)Tl. J Nucl Med. 2002 May;43(5):664-70.

[2]. Nagarajan R, et al. A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent. Cardiovasc Drugs Ther. 1996 Mar;10(1):31-8.

Chemical & Physical Properties

[ Density]:
1.262g/cm3

[ Boiling Point ]:
578.3ºC at 760mmHg

[ Molecular Formula ]:
C₁₈H₂₃NO₄

[ Molecular Weight ]:
317.38000

[ Flash Point ]:
195.1ºC

[ Exact Mass ]:
317.16300

[ PSA ]:
92.95000

[ LogP ]:
2.84020

Arbutamine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds