NH2-PEG6-Boc
Names
Biological Activity
[Description]:
NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
[Related Catalog]:
[Target]
PEGs
Alkyl/ether
Non-cleavable
[In Vitro]
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H39NO8
[ Molecular Weight ]:
409.51500
[ Exact Mass ]:
409.26800
[ PSA ]:
107.70000
[ LogP ]:
1.47680