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THP-PEG4-OH

Names

[ CAS No. ]:
128660-97-9

[ Name ]:
THP-PEG4-OH

[Synonym ]:
Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-
2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol

Biological Activity

[Description]:

THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
394.0±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H26O6

[ Molecular Weight ]:
278.342

[ Flash Point ]:
192.1±27.9 °C

[ Exact Mass ]:
278.172943

[ LogP ]:
-1.46

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.467

Related Compounds