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FR 122047 hydrochloride

Names

[ CAS No. ]:
130717-51-0

[ Name ]:
FR 122047 hydrochloride

Biological Activity

[Description]:

FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:28 nM (IC50)


[References]

[1]. Dohi M, et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol. 1993 Oct 19;243(2):179-84. 

[2]. Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54.

[3]. Ochi T, Goto T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol. 2002 Feb;135(3):782-8. 

Chemical & Physical Properties

[ Boiling Point ]:
562.7ºC at 760 mmHg

[ Molecular Formula ]:
C23H26ClN3O3S

[ Molecular Weight ]:
459.98900

[ Flash Point ]:
294.1ºC

[ Exact Mass ]:
459.13800

[ PSA ]:
83.14000

[ LogP ]:
4.55970

[ Vapour Pressure ]:
1.1E-12mmHg at 25°C

Related Compounds