4,9-Anhydrotetrodotoxin
Names
[ CAS No. ]:
13072-89-4
[ Name ]:
4,9-Anhydrotetrodotoxin
[Synonym ]:
Anhydro-epitetrodotoxin
anhydrotetrodotoxin
Biological Activity
[Description]:
4,9-Anhydrotetrodotoxin is a selective voltage-gated sodium channel (VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6[1].
[Related Catalog]:
[In Vitro]
4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample[1].
[References]
Chemical & Physical Properties
[ Density]:
3.07g/cm3
[ Boiling Point ]:
725.6ºC at 760mmHg
[ Molecular Formula ]:
C11H14N2O2
[ Molecular Weight ]:
206.24100
[ Flash Point ]:
392.6ºC
[ Exact Mass ]:
206.10600
[ PSA ]:
56.06000
[ LogP ]:
0.87730
[ Vapour Pressure ]:
2.63E-24mmHg at 25°C
[ Index of Refraction ]:
2.298