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Thiol-C9-PEG7

Names

[ CAS No. ]:
130727-44-5

[ Name ]:
Thiol-C9-PEG7

[Synonym ]:
MUHEG
3,6,9,12,15,18-Hexaoxanonacosan-1-ol,29-mercapto
Thiol-C9-PEG7

Biological Activity

[Description]:

Thiol-C9-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.023g/cm3

[ Boiling Point ]:
550.4ºC at 760mmHg

[ Molecular Formula ]:
C23H48O7S

[ Molecular Weight ]:
468.68800

[ Flash Point ]:
286.7ºC

[ Exact Mass ]:
468.31200

[ PSA ]:
114.41000

[ LogP ]:
3.51900

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.474

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Related Compounds