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2-Trifluoromethyl-2'-methoxychalcone

Names

[ CAS No. ]:
1309371-03-6

[ Name ]:
2-Trifluoromethyl-2'-methoxychalcone

[Synonym ]:
2-trifluoromethyl-2-hydroxy-3,3-diflouro-4-phenyloxetane
2-trifluoromethyl-2'-methoxychalone
(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one
4-hydroxy-1,1,1,3,3-pentafluoro-4-phenylbutan-2-one hemiacetal
2-Propen-1-one, 1-(2-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-, (2E)-

Biological Activity

[Description]:

2-Trifluoromethyl-2'-methoxychalcone is a chalcone derivative. 2-Trifluoromethyl-2'-methoxychalcone is a potent Nrf2 activator. 2-Trifluoromethyl-2'-methoxychalcone can be used for oxidative stress and inflammation related diseases research[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Inflammation/Immunology

[References]

[1]. Kumar V, et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. J Med Chem. 2011 Jun 23;54(12):4147-59.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
395.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H13F3O2

[ Molecular Weight ]:
306.28

[ Flash Point ]:
186.4±22.8 °C

[ Exact Mass ]:
306.086761

[ PSA ]:
26.30000

[ LogP ]:
4.71

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.550

Related Compounds