BnO-PEG1-CH2CO2tBu

Names

[ CAS No. ]:
1309451-06-6

[ Name ]:
BnO-PEG1-CH2CO2tBu

[Synonym ]:
MFCD28015768

Biological Activity

[Description]:

BnO-PEG1-CH2CO2tBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₂O₄

[ Molecular Weight ]:
266.33300

[ Exact Mass ]:
266.15200

[ PSA ]:
44.76000

[ LogP ]:
2.56150

[ Storage condition ]:
2-8℃

BnO-PEG1-CH2CO2tBu

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds