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Pimpinellin

Names

[ CAS No. ]:
131-12-4

[ Name ]:
Pimpinellin

[Synonym ]:
5,6-Dimethoxy-2H-furo[2,3-h]chromen-2-one
2H-Furo[2,3-h]-1-benzopyran-2-one, 5,6-dimethoxy-
5,6-dimethoxyfuro[2,3-h]chromen-2-one
4-Hydroxy-6,7-dimethoxy-5-benzofuranacrylic Acid d-Lactone
5,6-Dimethoxy-2H-furo[2,3-h]-1-benzopyran-2-one
Pimpinellin

Biological Activity

[Description]:

Pimpinellin is a constituent of Cyrtomium fortumei (J.). Pimpinellin inhibits the growth of tumor cells via the induction of tumor cell apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Pimpinellin has potent cytotoxic activities against the three tumor cells MGC-803, PC3, and A375, with the IC50 values of 14.4±0.3 μM, 20.4±0.5 μM, and 29.2±0.6 μM, respectively. Pimpinellin inhibits the growth of MGC-803 cells via the induction of tumor cell apoptosis, with apoptosis ratio of 27.44% after 72 h of treatment at 20 μM[1].

[References]

[1]. Yang S, et al. Discovery and antitumor activities of constituents from Cyrtomium fortumei (J.) Smith rhizomes. Chem Cent J. 2013 Feb 4;7(1):24.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
441.0±45.0 °C at 760 mmHg

[ Melting Point ]:
119°

[ Molecular Formula ]:
C13H10O5

[ Molecular Weight ]:
246.215

[ Flash Point ]:
220.5±28.7 °C

[ Exact Mass ]:
246.052826

[ PSA ]:
61.81000

[ LogP ]:
2.06

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.612

[ Storage condition ]:
2-8C

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds