PDZ1 Domain inhibitor peptide

Names

[ Name ]:
PDZ1 Domain inhibitor peptide

[Synonym ]:
L-Valine, N-[[(2S,5S,14S)-14-[[(2S)-6-amino-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-1-oxohexyl]amino]-2-(1-hydroxyethyl)-3,8,15-trioxo-1,4,9-triazacyclopentadec-5-yl]carbonyl]-L-alanyl-
N-({(2S,5S,14S)-2-(1-Hydroxyethyl)-3,8,15-trioxo-14-[(L-tyrosyl-L-lysyl)amino]-1,4,9-triazacyclopentadecan-5-yl}carbonyl)-L-alanyl-L-valine

Biological Activity

[Description]:

PDZ1 Domain inhibitor peptide, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1304.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₈H₆₁N₉O₁₁

[ Molecular Weight ]:
819.945

[ Flash Point ]:
742.5±34.3 °C

[ Exact Mass ]:
819.449036

[ LogP ]:
-2.24

[ Appearance of Characters ]:
White lyophilised solid

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.597

[ Storage condition ]:
Desiccate at -20°C

[ Water Solubility ]:
Soluble to 1 mg/ml in 5% acetonitrile / H2O and to 4 mg/ml in DMSO

PDZ1 Domain inhibitor peptide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds