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m-PEG8-CH2CH2-NHS ester

Names

[ CAS No. ]:
1316189-13-5

[ Name ]:
m-PEG8-CH2CH2-NHS ester

[Synonym ]:
2,5-Pyrrolidinedione, 1-[(1-oxo-4,7,10,13,16,19,22,25,28-nonaoxanonacos-1-yl)oxy]-
1-[(29-Oxo-2,5,8,11,14,17,20,23,26-nonaoxanonacosan-29-yl)oxy]-2,5-pyrrolidinedione

Biological Activity

[Description]:

m-PEG8-CH2CH2-NHS ester is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2.

[2]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
598.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H43NO13

[ Molecular Weight ]:
553.597

[ Flash Point ]:
315.7±32.9 °C

[ Exact Mass ]:
553.273438

[ LogP ]:
-4.66

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.489

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds