Chlorthenoxazine

Names

[ CAS No. ]:
132-89-8

[ Name ]:
Chlorthenoxazine

[Synonym ]:
2-(2-chloro-ethyl)-2,3-dihydro-benz[e][1,3]oxazin-4-one
2-(2-chloro-ethyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one
Chlorethylbenzmethoxazone
Ossipirina
EINECS 205-082-3
Ossazone
Reumagrip
Reugaril
Apirazin
2-(2-Chlor-aethyl)-2,3-dihydro-benz[e][1,3]oxazin-4-on
chlorothenoxazine
Valmorin
Valtorin
Chlorthenoxazin
chlorthenoxazine

Biological Activity

[Description]:

Chlorthenoxazine is a nonsteroidal anti-inflammatory drug.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.253g/cm3

[ Boiling Point ]:
449.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₀H₁₀ClNO₂

[ Molecular Weight ]:
211.64500

[ Flash Point ]:
225.8ºC

[ Exact Mass ]:
211.04000

[ PSA ]:
38.33000

[ LogP ]:
2.09260

[ Vapour Pressure ]:
2.78E-08mmHg at 25°C

[ Index of Refraction ]:
1.541

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3675000

CHEMICAL NAME :: 4H-1,3-Benzoxazin-4-one, 2-(2-chloroethyl)-2,3-dihydro-

CAS REGISTRY NUMBER :: 132-89-8

BEILSTEIN REFERENCE NO. :: 0170863

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H10-Cl-N-O2

MOLECULAR WEIGHT :: 211.66

WISWESSER LINE NOTATION :: T66 BVM EO DHJ D2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,651,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 1,36,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11155 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,884,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1702 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 13,884,1963

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%