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5alpha-Hydroxycostic acid

Names

[ CAS No. ]:
132185-83-2

[ Name ]:
5alpha-Hydroxycostic acid

[Synonym ]:
2-[(2R,4aR,8aR)-8a-Hydroxy-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
2-Naphthaleneacetic acid, decahydro-8a-hydroxy-4a-methyl-α,8-bis(methylene)-, (2R,4aR,8aR)-

Biological Activity

[Description]:

5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating VEGF/VEGFR2 and Ang2/Tie2 pathways[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. Liang N, et, al. Two natural eudesmane-type sesquiterpenes from Laggera alata inhibit angiogenesis and suppress breast cancer cell migration through VEGF- and Angiopoietin 2-mediated signaling pathways. Int J Oncol. 2017 Jul;51(1):213-222.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
406.4±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H22O3

[ Molecular Weight ]:
250.333

[ Flash Point ]:
213.8±23.3 °C

[ Exact Mass ]:
250.156891

[ PSA ]:
57.53000

[ LogP ]:
3.19

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.540

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds