<Suppliers Price>

Xanthurenic acid-d4

Names

[ CAS No. ]:
1329611-28-0

[ Name ]:
Xanthurenic acid-d4

[Synonym ]:
2-Quinoline-3,5,6,7-d4-carboxylic acid, 4,8-dihydroxy-
4,8-Dihydroxy-2-(2H4)quinolinecarboxylic acid

Biological Activity

[Description]:

Xanthurenic acid-d4 is the deuterium labeled Xanthurenic acid[1]. Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> GPCR/G Protein >> mGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Copeland CS, et al. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology. 2013 Mar;66:133-42.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
514.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H3D4NO4

[ Molecular Weight ]:
209.191

[ Flash Point ]:
264.9±30.1 °C

[ Exact Mass ]:
209.062622

[ LogP ]:
2.64

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.779

Related Compounds