PK-THPP

Names

[ Name ]:
PK-THPP

[Synonym ]:
pk-thpp

Biological Activity

[Description]:

PK-THPP is a potent TWIK-related acid-sensitive K(+) ion channel (TASK-3 ion channel) blocker (IC50s are 35 nM and 300 nM for TASK-3 and TASK-1, respectively)[1]. PK-THPP increases breathing rate and induces respiratory alkalosis in rats[2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Coburn CA,et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem. 2012 Jan 2;7(1):123-33.

[2]. Cotten JF. TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth Analg. 2013 Apr;116(4):810-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₂N₄O₂

[ Molecular Weight ]:
468.59000

[ Exact Mass ]:
468.25300

[ PSA ]:
66.40000

[ LogP ]:
4.93060

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

PK-THPP

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds