vinaxanthone

Names

[ Name ]:
vinaxanthone

[Synonym ]:
Vinaxanthone
411F

Biological Activity

[Description]:

Vinaxanthone (SM-345431) is a potent and selective semaphorin3A inhibitor. Vinaxanthone exhibits semaphorin3A inhibiting activity with an IC50 of 0.1-0.2 μM[1]. Vinaxanthone shows selective inhibitory activity against phospholipase C (PLC) from rat brain, mutine colon 26 Adenocarcinoma and murine fibroblasts NIH3T3 with IC50s being 5.4, 9.3 and 44 μM, respectively[2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[References]

[1]. Masahiro Aoki, et al. Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceum. Tetrahedron Letters. 1991, 32 (36):4737-4740.

[2]. Liang Zhang, et al. Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition. Mol Brain. 2014 Mar 10;7:14.

Chemical & Physical Properties

[ Density]:
1.772g/cm3

[ Boiling Point ]:
1064.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₁₆O₁₄

[ Molecular Weight ]:
576.41800

[ Flash Point ]:
357.6ºC

[ Exact Mass ]:
576.05400

[ PSA ]:
250.08000

[ LogP ]:
3.34360

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.768

vinaxanthone

Names

Biological Activity

Chemical & Physical Properties

Related Compounds