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Lipoamido-PEG8-acid

Names

[ CAS No. ]:
1334172-70-1

[ Name ]:
Lipoamido-PEG8-acid

[Synonym ]:
33-(1,2-Dithiolan-3-yl)-29-oxo-4,7,10,13,16,19,22,25-octaoxa-28-azatritriacontan-1-oic acid
4,7,10,13,16,19,22,25-Octaoxa-28-azatritriacontan-1-oic acid, 33-(1,2-dithiolan-3-yl)-29-oxo-

Biological Activity

[Description]:

Lipoamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
748.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H51NO11S2

[ Molecular Weight ]:
629.824

[ Flash Point ]:
406.4±32.9 °C

[ Exact Mass ]:
629.290344

[ LogP ]:
-1.15

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.507

Related Compounds