OPSS-PEG8-COOH

Names

[ Name ]:
OPSS-PEG8-COOH

[Synonym ]:
29-Oxo-31-(2-pyridinyldisulfanyl)-4,7,10,13,16,19,22,25-octaoxa-28-azahentriacontan-1-oic acid
4,7,10,13,16,19,22,25-Octaoxa-28-azahentriacontan-1-oic acid, 29-oxo-31-(2-pyridinyldithio)-

Biological Activity

[Description]:

OPSS-PEG8-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
768.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₄₆N₂O₁₁S₂

[ Molecular Weight ]:
638.791

[ Flash Point ]:
418.6±32.9 °C

[ Exact Mass ]:
638.254272

[ LogP ]:
-0.80

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.541

OPSS-PEG8-COOH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds