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EGFR-IN-16

Names

[ CAS No. ]:
133550-22-8

[ Name ]:
EGFR-IN-16

Biological Activity

[Description]:

EGFR-IN-16 (compound 3) is a potent EGFR inhibitor with pIC50 of 4.85 and 4.74 for EGFR and HER-2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR:4.85 (pIC50)

HER2:4.74 (pIC50)


[References]

[1]. Kamath S, et al. Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors. J Med Chem. 2003;46(22):4657-4668.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H11NO3

[ Molecular Weight ]:
265.26

Related Compounds