Pancreastatin (33-48) (human) trifluoroacetate salt

Names

[ Name ]:
Pancreastatin (33-48) (human) trifluoroacetate salt

[Synonym ]:
Pancreastatin Fragment 37-52 human

Biological Activity

[Description]:

Pancreastatin (37-52), human is a pancreastatin fragment. Pancreastatin a CgA-derived peptide (CgA residues 250–301) with biological activity, inhibited the releasing of insulin by islet beta cells[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Qiao XW, et al. Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. BMC Endocr Disord. 2014 Aug 7;14:64.

[2]. O'Dorisio TM, et al. Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior. Pancreas. 2010 Jul;39(5):611-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₈H₁₂₃N₂₁O₂₇S

[ Molecular Weight ]:
1819.00000

[ Exact Mass ]:
1817.86000

[ PSA ]:
813.61000

[ LogP ]:
1.76890

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties.

Cell. Mol. Life Sci. 64 , 2863-2886, (2007)

Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The...

Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin.

Regul. Pept. 161 , 8-14, (2010)

Pancreastatin is one of the regulatory peptides derived from intracellular and/or extracellular processing of chromogranin A, the soluble acidic protein present in the secretory granules of the neuroe...

Effect of chromogranin A (pancreastatin) fragment on invasion of prostate cancer cells.

Cancer Lett. 147 , 207-213, (1999)

We investigated the effect of chromogranin A (pancreastatin) fragment on the invasion of PC-3, DU-145 and LNCaP prostate cancer cells through a reconstituted basement membrane (Matrigel) using a Trans...