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Misoprostol acid D5

Names

[ CAS No. ]:
1337917-44-8

[ Name ]:
Misoprostol acid D5

[Synonym ]:
Prost-13-en-1-oic-17,17-d acid, 11,16-dihydroxy-16-(methyl-d)-9-oxo-, (11α,13E)-
(11α,13E)-11,16-Dihydroxy-16-(H)methyl-9-oxo(17,17-H)prost-13-en-1-oic acid

Biological Activity

[Description]:

Misoprostol acid D5 is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
Research Areas >> Inflammation/Immunology

[References]

[1]. Vijaya Bharathi D, et al. Development and validation of highly sensitive method for determination of misoprostol free acid in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Sep 15;879(26):2827-33.

[2]. Schmidt-Hansen M, et al. Simultaneous compared to interval administration of mifepristone and misoprostol for medical abortion up to 10+0 weeks' gestation: a systematic review with meta-analyses. BMJ Sex Reprod Health. 2020 Feb 20. pii: bmjsrh-2019-200448.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
538.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H31D5O5

[ Molecular Weight ]:
373.538

[ Flash Point ]:
293.4±26.6 °C

[ Exact Mass ]:
373.287659

[ PSA ]:
94.83000

[ LogP ]:
2.45

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.543

Related Compounds