sodium ascorbate

Names

[ CAS No. ]:
134-03-2

[ Name ]:
sodium ascorbate

[Synonym ]:
EINECS 205-126-1
Sodium ascorbate
L-Ascorbic Acid Sodium Salt
Vitamine C sodium salt,Vitamin C sodium salt
(+)-Sodium L-ascorbate (L(+)-Ascorbic acid sodium salt
SodiuM L-Ascorbate
L(+)-Ascorbic acid sodium salt,Vitamin C sodium salt
MFCD00082340
Vitamin C Sodium Salt
L(+)-Ascorbic acid sodium salt,E301

Biological Activity

[Description]:

L-Ascorbic acid (sodium) is a more bioavailable form of vitamin C that is an antioxidant agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Natural Products >> Others

[In Vitro]

Vitamin C (L-ascorbic acid), a known enhancer of collagen deposition, has also been identified as an inhibitor of elastogenesis[1]. The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by sodium L-ascorbate (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[2].

[In Vivo]

Tg rats treated with sodium L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium L-ascorbate (15.4%). Independent of the sodium L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[3]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[4].

[Animal admin]

A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.

[References]

[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.

[2]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50.

[3]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.

[4]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.799 g/cm3

[ Boiling Point ]:
552.7ºC at 760 mmHg

[ Melting Point ]:
220 °C (dec.)(lit.)

[ Molecular Formula ]:
C₆H₇NaO₆

[ Molecular Weight ]:
198.106

[ Flash Point ]:
238.2ºC

[ Exact Mass ]:
198.014038

[ PSA ]:
110.05000

[ Vapour Pressure ]:
1.62E-14mmHg at 25°C

[ Index of Refraction ]:
105.5 ° (C=10, H2O)

[ Water Solubility ]:
620 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI7671000

CHEMICAL NAME :: L-Ascorbic acid, monosodium salt

CAS REGISTRY NUMBER :: 134-03-2

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H7-O6.Na

MOLECULAR WEIGHT :: 198.12

WISWESSER LINE NOTATION :: T5OV EHJ CQ DQ EYQ1Q &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 500 umol/L

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 8,299,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0461 No. of Facilities: 474 (estimated) No. of Industries: 5 No. of Occupations: 16 No. of Employees: 16211 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0461 No. of Facilities: 705 (estimated) No. of Industries: 11 No. of Occupations: 28 No. of Employees: 24087 (estimated) No. of Female Employees: 15231 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R68

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
CI7671000

Precursor & DownStream

Precursor

DownStream

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