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Acid-C2-PEG4-C2-NHS ester

Names

[ CAS No. ]:
1343476-41-4

[ Name ]:
Acid-C2-PEG4-C2-NHS ester

[Synonym ]:
19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecan-1-oic acid
4,7,10,13,16-Pentaoxanonadecan-1-oic acid, 19-[(2,5-dioxo-1-pyrrolidinyl)oxy]-19-oxo-

Biological Activity

[Description]:

Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
574.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H29NO11

[ Molecular Weight ]:
435.423

[ Flash Point ]:
301.5±32.9 °C

[ Exact Mass ]:
435.174072

[ LogP ]:
-3.42

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.509

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds