aceprometazine

Names

[ Name ]:
aceprometazine

[Synonym ]:
Aceprometazin
1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]ethanone
aceprometazine
Aceprometazinum
Acepromethazine
Ethanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
Aceprometazina
EINECS 236-661-9

Biological Activity

[Description]:

Aceprometazine (1664CB) is an orally active antipsychotic. Aceprometazine can be used in the study of psychiatric disorders, such as depression[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
490.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂N₂OS

[ Molecular Weight ]:
326.456

[ Flash Point ]:
250.2±28.7 °C

[ Exact Mass ]:
326.145294

[ PSA ]:
48.85000

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.608

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB2200000

CHEMICAL NAME :: Ketone, 10-(2-(dimethylamino)propyl)phenothiazin-2-yl methyl

CAS REGISTRY NUMBER :: 13461-01-3

BEILSTEIN REFERENCE NO. :: 0038528

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H22-N2-O-S

MOLECULAR WEIGHT :: 326.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 517 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 21,543,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 21,543,1964

Safety Information

[ HS Code ]:
2934300000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%