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Esmolol-d7 (hydrochloride)

Names

[ CAS No. ]:
1346598-13-7

[ Name ]:
Esmolol-d7 (hydrochloride)

[Synonym ]:
Benzenepropanoic acid, 4-[2-hydroxy-3-[[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]propoxy]-, methyl ester, hydrochloride (1:1)
Esmolol-d7 (hydrochloride)
Methyl 3-(4-{2-hydroxy-3-[(2H7)-2-propanylamino]propoxy}phenyl)propanoate hydrochloride (1:1)

Biological Activity

[Description]:

Esmolol-d7 hydrochloride is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Research Areas >> Endocrinology
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Signaling Pathways >> Autophagy >> Mitophagy

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Wiest D. Esmolol. A review of its therapeutic efficacy and pharmacokinetic characteristics. Clin Pharmacokinet. 1995;28(3):190-202.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H19D7ClNO4

[ Molecular Weight ]:
338.878

[ Exact Mass ]:
338.198975

Related Compounds