Lamivudine
Names
[ CAS No. ]:
134678-17-4
[ Name ]:
Lamivudine
[Synonym ]:
2(1H)-Pyrimidinone, 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-
3TC
Heptodin
cent
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
Lamivudine
Zeffix
Zefix
Hepitec
Heptivir
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2',3'-Dideoxy-3'-thiacytidine
Heptovir
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
MFCD00869739
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cystosine
4-Amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Epivir
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
3&L-SddC
Biological Activity
[Description]:
[Related Catalog]:
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.7±0.1 g/cm3
[ Boiling Point ]:
475.4±55.0 °C at 760 mmHg
[ Melting Point ]:
177 °C
[ Molecular Formula ]:
C8H11N3O3S
[ Molecular Weight ]:
229.256
[ Flash Point ]:
241.3±31.5 °C
[ Exact Mass ]:
229.052109
[ PSA ]:
115.67000
[ LogP ]:
-0.71
[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C
[ Index of Refraction ]:
1.755
[ Storage condition ]:
Freezer
MSDS
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H361
[ Precautionary Statements ]:
P281
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
63
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UW7361333
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2938901000
[ Summary ]:
HS: 2938901000. 4-amino-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1h)-one. VAT:17.0%. tax rebate rate:13.0%. supervision conditions:None. MFN tarrif:6.5%. general tariff:20.0%
Articles
Drug Metab. Dispos. 43(1) , 147-53, (2014)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake...
Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.Anal. Bioanal. Chem 407(8) , 2073-84, (2015)
A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtrici...
The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium.Environ. Mol. Mutagen. 54(4) , 268-80, (2013)
The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses...