2-Phthalimidehydroxy-acetic acid

Names

[ Name ]:
2-Phthalimidehydroxy-acetic acid

[Synonym ]:
N-(Phth)-AOGly-OH
phthalmidooxyacetic acid
PhthN-O-Gly-OH
2-((1,3-dioxoisoindolin-2-yl)oxy)acetic acid
phthalimidooxyacetic acid
phthalimido-aminooxyacetic acid
Pht-Aoaa-OH
Acetic acid,[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]

Biological Activity

[Description]:

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₇NO₅

[ Molecular Weight ]:
221.16600

[ Exact Mass ]:
221.03200

[ PSA ]:
83.91000

[ LogP ]:
0.23670

2-Phthalimidehydroxy-acetic acid

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds