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Olmesartan methyl ester

Names

[ CAS No. ]:
1347262-29-6

[ Name ]:
Olmesartan methyl ester

[Synonym ]:
Methyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate
MFCD24386461
1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, methyl ester

Biological Activity

[Description]:

Olmesartan methyl ester is an intermediate in the synthesis of Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor antagonist with IC50 of 66.2 μM[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor

[References]

[1]. Dimitrios Ntountaniotis, et al. An efficient synthetic method and theoretical calculations of olmesartan methyl ether: study of biological function of AT1 antagonism. Comb Chem High Throughput Screen. 2014;17(8):652-62.

[2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
712.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H28N6O3

[ Molecular Weight ]:
460.528

[ Flash Point ]:
384.4±35.7 °C

[ Exact Mass ]:
460.222290

[ LogP ]:
4.03

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.645

Related Compounds