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Propargyl-PEG3-acid

Names

[ CAS No. ]:
1347760-82-0

[ Name ]:
Propargyl-PEG3-acid

[Synonym ]:
Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-
3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid

Biological Activity

[Description]:

Propargyl-PEG3-acid is a non-cleavable (3 unit PEG) ADC linker and also a PEG-based PROTAC linker that can be used to synthesis 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Farzam A, et al. A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death. Redox Biol. 2020 Jan;28:101377.

[2]. Albone, Earl F, et al. ERIBULIN-BASED ANTIBODY-DRUG CONJUGATES AND METHODS OF USE. Patent. 20170252458.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
348.0±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H16O5

[ Molecular Weight ]:
216.231

[ Flash Point ]:
131.8±18.6 °C

[ Exact Mass ]:
216.099777

[ LogP ]:
-0.44

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.467

Related Compounds