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Propargyl-PEG8-OH

Names

[ CAS No. ]:
1351556-81-4

[ Name ]:
Propargyl-PEG8-OH

[Synonym ]:
MFCD27635157
3,6,9,12,15,18,21,24-Octaoxaheptacos-26-yn-1-ol

Biological Activity

[Description]:

Propargyl-PEG8-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Goswami LN, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery. Org Biomol Chem. 2013 Feb 21;11(7):1116-26.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
483.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H36O9

[ Molecular Weight ]:
408.484

[ Flash Point ]:
246.2±27.3 °C

[ Exact Mass ]:
408.235931

[ LogP ]:
-2.76

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.465

Related Compounds