Orismilast

Names

[ Name ]:
Orismilast

[Synonym ]:
Leo-32731
Ethanone, 2-(3,5-dichloro-1-oxido-4-pyridinyl)-1-[7-(difluoromethoxy)-2',3',5',6'-tetrahydro-1',1'-dioxidospiro[1,3-benzodioxole-2,4'-[4H]thiopyran]-4-yl]-
2-(3,5-Dichloro-1-oxido-4-pyridinyl)-1-[7-(difluoromethoxy)-1',1'-dioxido-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-thiopyran]-4-yl]ethanone

Biological Activity

[Description]:

Orismilast (LEO-32731) is a PDE4 inhibitor used for the research of inflammatory diseases[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

Research Areas >> Inflammation/Immunology

[References]

[1]. Nielsen,et al.Preparation of benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors.WO2011160632A1.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
788.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₅Cl₂F₂NO₇S

[ Molecular Weight ]:
510.29

[ Flash Point ]:
430.9±32.9 °C

[ Exact Mass ]:
508.991425

[ LogP ]:
0.82

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.649