N-Cyclohexyl-6-Methyl-2-[4-(4-Morpholinyl]-imidazo[1,2-a]pyridin-3-amine

Names

[ Name ]:
N-Cyclohexyl-6-Methyl-2-[4-(4-Morpholinyl]-imidazo[1,2-a]pyridin-3-amine

[Synonym ]:
N-cyclohexyl-6-methyl-2-(4-morpholinophenyl)imidazo[1,2-a]pyridin-3-amine

Biological Activity

[Description]:

EP6 is a potent 5-Lipoxygenase (5-LO) inhibitor. EP6 inhibits the cell viability of tumor cells without mutagenic activity. EP6 can be used in research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase

[Target]

5-Lipoxygenase:0.05 μM (IC50)

[In Vitro]

EP6 抑制完整多形核白细胞中的 5-LO 活性，IC50 值为 0.16 μM，在无细胞试验中表现出完全抑制效力（纯化的 5-LO 的 IC50 值为 0.05 μM）[1]。

[References]

[1]. Wisniewska JM, et, al. Molecular characterization of EP6--a novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochem Pharmacol. 2012 Jan 15;83(2):228-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₀N₄O

[ Molecular Weight ]:
390.52

[ Exact Mass ]:
390.24200

[ PSA ]:
41.80000

[ LogP ]:
5.02890