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trans-Ned 19

Names

[ CAS No. ]:
1354235-96-3

[ Name ]:
trans-Ned 19

Biological Activity

[Description]:

trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease

[Target]

Ca2+


[References]

[1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H31FN4O3

[ Molecular Weight ]:
514.59100

[ Exact Mass ]:
514.23800

[ PSA ]:
80.83000

[ LogP ]:
4.65780

[ Storage condition ]:
-20°C

Related Compounds