Strontium Ranelate

Names

[ Name ]:
Strontium Ranelate

[Synonym ]:
3-Thiopheneacetic acid, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-
5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyano-2-thiophenecarboxylic acid
5-[Bis(carboxymethyl)amino]-3-(carboxymethyl)-4-cyanothiophene-2-carboxylic acid
Strontium Ranelate
Ranelic Acid Strontium Salt

Biological Activity

[Description]:

Strontium ranelate(S12911) stimulates the calcium sensing receptors (CaSR) and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.IC50 value:Target: CaSRStrontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Strontium Ranelate acts by increasing bone formation and decreasing bone resorption, thus rebalancing bone turnover in favour of bone formation, an effect that results in increased bone mass and strength. Commonly used as an antiosteoporotic. Strontium Ranelate has shown efficacy in preventing early postmenopausal bone loss and reducing the risk of hip fracture in women with postmenopausal osteoporosis.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CaSR

Research Areas >> Metabolic Disease

[References]

[1]. Bonnelye E, Chabadel A, Saltel F, Jurdic P. Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone. 2008 Jan;42(1):129-38. Epub 2007 Sep 12.

[2]. Marie PJ. Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation. Curr Opin Rheumatol. 2006 Jun;18 Suppl 1:S11-5.

[3]. P. J. Marie .Strontium ranelate: a novel mode of action optimizing bone formation and resorption. Osteoporosis International. 2005,16(1): S7-S10

[4]. Sorbera, L.A., Castaner, et al . Strontium Ranelate .Drugs Fut 2003, 28(4): 328

[5]. J Buehler, P Chappuis, J.L Saffar, et al. Strontium ranelate inhibits bone resorption while maintaining bone formation in alveolar bone in monkeys (Macaca fascicularis). Bone. 2001,29(2): 176-179.

[Related Small Molecules]

NPS-2143 | Evocalcet | Calcium-Sensing Receptor Antagonists I | SB-423562

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
778.8±60.0 °C at 760 mmHg

[ Melting Point ]:
>310°C (dec.)

[ Molecular Formula ]:
C₁₂H₆N₂O₈SSr₂

[ Molecular Weight ]:
513.49

[ Flash Point ]:
424.8±32.9 °C

[ PSA ]:
160.47000

[ LogP ]:
-0.90

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.695

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
H2O: soluble1mg/mL, clear (warmed)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332

[ Precautionary Statements ]:
P280

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
3077

[ RTECS ]:
XM7581000

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000