Propargyl-PEG6-Boc

Names

[ Name ]:
Propargyl-PEG6-Boc

[Synonym ]:
4,7,10,13,16,19-Hexaoxadocos-21-yn-1-oic acid, 1,1-dimethylethyl ester
MFCD28950777
2-Methyl-2-propanyl 4,7,10,13,16,19-hexaoxadocos-21-yn-1-oate

Biological Activity

[Description]:

Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Noah Bell, et al. Compounds and methods for inhibiting phosphate transport. WO2012054110A2.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
458.4±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₃₆O₈

[ Molecular Weight ]:
404.495

[ Flash Point ]:
194.1±27.4 °C

[ Exact Mass ]:
404.241028

[ LogP ]:
0.17

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.458

Propargyl-PEG6-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds