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AZD-3463

Names

[ CAS No. ]:
1356962-20-3

[ Name ]:
AZD-3463

[Synonym ]:
ALK/IGF1R inhibitor||AZD3463|AZD 3463
N-[4-(4-Amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-2-pyrimidinamine
AZD3463
2-Pyrimidinamine, N-[4-(4-amino-1-piperidinyl)-2-methoxyphenyl]-5-chloro-4-(1H-indol-3-yl)-
ALK/IGF1R inhibitor
S7106
N-(4-(4-aminopiperidin-1-yl)-2-methoxyphenyl)-5-chloro-4-(1H-indol-3-yl)pyrimidin-2-amine
CS-1382
AZD-3463

Biological Activity

[Description]:

AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib.IC50 Value:Target: ALK/IGF1R

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IGF-1R
Research Areas >> Cancer

[Related Small Molecules]

Brigatinib | lorlatinib | Alectinib (CH5424802) | OSI-906(Linsitinib) | Entrectinib | BMS-754807 | Picropodophyllotoxin | TAE684(NVP-TAE684) | NVP-AEW541 | BMS-536924 | Repotrectinib | Ensartinib | AP26113 | XL228 | K 02288

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
723.6±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H25ClN6O

[ Molecular Weight ]:
448.948

[ Flash Point ]:
391.4±35.7 °C

[ Exact Mass ]:
448.177826

[ PSA ]:
92.09000

[ LogP ]:
3.11

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.693

[ Storage condition ]:
-20℃

Precursor & DownStream

Precursor

DownStream

Related Compounds