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OG-L002

Names

[ CAS No. ]:
1357302-64-7

[ Name ]:
OG-L002

[Synonym ]:
4'-[(1R,2S)-2-Aminocyclopropyl]-3-biphenylol
[1,1'-Biphenyl]-3-ol, 4'-[(1R,2S)-2-aminocyclopropyl]-
4'-((1R,2S)-2-Aminocyclopropyl)biphenyl-3-ol
OG-L002

Biological Activity

[Description]:

OG-L002 is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 potently inhibits the expression of HSV IEgenes[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection
Signaling Pathways >> Epigenetics >> Histone Demethylase
Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

[Target]

IC50: 0.02 μM (LSD1), 1.38 μM (MAO-A), 0.72 μM (MAO-B), HSV IE[1]


[In Vitro]

OG-L002 inhibits viral IE gene expression in both cells with a significantly reduced IC50 (IC50: ~10 µM in HeLa cells; IC50: ~3 µM in HFF cells) relative to the control MAOI TCP (IC50: ~1 mM)[1].

[In Vivo]

OG-L002 (i.p.; 6-40 mg/kg; daily; for 7 days) reduces the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection[1]. Animal Model: 4-week-old BALB/c female mice[1] Dosage: 6, 20, 40 mg/kg Administration: Intraperitoneal; daily; for 7 days Result: Reduced the levels of detectable viral genomes in the ganglia in a dose-dependent manner at both 3 and 5 days postinfection.

[References]

[1]. Liang Y, et al. A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. mBio. 2013 Feb 5;4(1):e00558-12.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
416.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H15NO

[ Molecular Weight ]:
225.286

[ Flash Point ]:
205.8±28.7 °C

[ Exact Mass ]:
225.115356

[ PSA ]:
46.25000

[ LogP ]:
2.27

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Very slightly soluble (0.22 g/L) (25 ºC)

Related Compounds