(3R,4R)-A2-32-01

Names

[ Name ]:
(3R,4R)-A2-32-01

Biological Activity

[Description]:

(3R,4R)-A2-32-01 (compound 2), an anti-virulence drug, is a specific caseinolytic protein proteases (ClpP) inhibitor with an EC50 of 4.5 μM, and shows a tolerable cytotoxicity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

(3R,4R)-A2-32-01 inhibits hemolysis with an ED50 of 15 nmol on blood agar plates[1]. (3R,4R)-A2-32-01 exhibits EC50s of 50 μM and 75 μM in dropping metabolic activity of NIH3T3 fibroblasts and HaCat keratinocytes, respectively[1].

[References]

[1]. Zeiler E, et al. Development and characterization of improved β-lactone-based anti-virulence drugs targetingClpP. Bioorg Med Chem. 2012 Jan 15;20(2):583-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₇NO₂

[ Molecular Weight ]:
301.42

(3R,4R)-A2-32-01

Names

Biological Activity

Chemical & Physical Properties

Related Compounds