LY 274614

Names

[ CAS No. ]:
136109-04-1

[ Name ]:
LY 274614

[Synonym ]:
6-(phosphonomethyl)decahydroisoquinoline-3-carboxylic acid
(3S,4aR,6S,8aR)-6-(phosphonomethyl)decahydroisoquinoline-3-carboxylic acid
3-Isoquinolinecarboxylicacid,decahydro-6-(phosphonomethyl)-,(3S,4aR,6S,8aR)

Biological Activity

[Description]:

LY 274614 is an orally active, competitive NMDA receptor antagonist. LY 274614 can be used for Neurological Disease study[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Schoepp DD, et al. Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist. J Neural Transm Gen Sect. 1991;85(2):131-143.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H20NO5P

[ Molecular Weight ]:
277.25

[ Exact Mass ]:
277.10800

[ PSA ]:
116.67000

[ LogP ]:
0.97190

[ Vapour Pressure ]:
4.5E-13mmHg at 25°C

Related Compounds