Alprenolol

[Description]:

Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist.The reference for administration is 10 mg/kg.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Cancer

[References]

[1]. Schreiber R et al. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):211-5.

[2]. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2

[Related Small Molecules]

[ Density]:
1.007g/cm3

[ Boiling Point ]:
383.4ºC at 760mmHg

[ Melting Point ]:
57.5°C

[ Molecular Formula ]:
C₁₅H₂₃NO₂

[ Molecular Weight ]:
249.34900

[ Flash Point ]:
185.7ºC

[ Exact Mass ]:
249.17300

[ PSA ]:
41.49000

[ LogP ]:
2.54370

[ Vapour Pressure ]:
1.46E-06mmHg at 25°C

[ Index of Refraction ]:
1.5250 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA5350000

CHEMICAL NAME :: 2-Propanol, 1-(o-allylphenoxy)-3-(isopropylamino)-

CAS REGISTRY NUMBER :: 13655-52-2

LAST UPDATED :: 199606

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H23-N-O2

MOLECULAR WEIGHT :: 249.39

WISWESSER LINE NOTATION :: 1Y1&M1YQ1OR B2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UGLAAD Ugeskrift for Laeger. Doctor's Weekly. (Almindelige Danske Laegeforening, Esplanaden 8C4, 1045 Copenhagen K, Denmark) V.1- 1839- Volume(issue)/page/year: 139,2817,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 18,151,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1022,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 8,137,1974

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Click to get detail synthetic route

Related Compounds