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Chloroacetamido-PEG4-C2-Boc

Names

[ CAS No. ]:
1365655-90-8

[ Name ]:
Chloroacetamido-PEG4-C2-Boc

[Synonym ]:
6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-chloro-2-oxo-, 1,1-dimethylethyl ester
MFCD22056319
2-Methyl-2-propanyl 1-chloro-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oate

Biological Activity

[Description]:

Chloroacetamido-PEG4-C2-Boc is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H32ClNO7

[ Molecular Weight ]:
397.892

[ Flash Point ]:
272.9±30.1 °C

[ Exact Mass ]:
397.186737

[ LogP ]:
-0.24

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Storage condition ]:
2-8°C

Related Compounds